Indeed, ChrY is not essential to life, and large deletions in the long arm of the murine ChrY have no overt phenotypic effects except on spermatogenesis and sex ratio distortion [ 5- 7].
But although this is interesting, the normalization is indeed also confusing and not essential for our study.
Although they were not found in all human isolates, they were notably found only in human-invasive isolates, suggesting that they may indeed play a useful if not essential role in invasive disease.
Indeed, although insulin/IGF signaling is not essential in oocyte conditional knockout mice [ 46], IGF-1 significantly increases oocyte maturation [ 47].
It should be pointed out, however, that a nonconformist lifestyle is not essential to creativity; indeed, many creative individuals lead quite ordinary lives, expressing their autonomy mainly in their unconventional ideas and work.
Rather, they are themselves essential unities, and indeed not predicable at all.
Indeed, lesion studies indicate that these regions are not essential for empathy induction [ 35].
Indeed, Bonnie & de Waal [39] found that rewards are not essential for social learning in brown capuchin monkeys.
In this case, while Wac is not essential to mitosis in vivo, its function is indeed required for chromosome alignment and segregation during female meiosis.
