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Here in our paper we focus on how Sema-Nrp signaling alters Hh transduction, but indeed more needs to be done to understand how PKA affects Hh transduction, especially how PKA differentially regulates Gli2 activation and Gli3 processing.
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I will say up front that indeed much more needs to be done.
More needs to happen.
More needs to be done.
Much more needs to happen.
Indeed, more work needs to be done here.
Many more need to.
Elderly patients with comorbidities and complex healthcare needs are indeed more prone to receive long-term care, and therefore more likely to suffer a delay in being discharged from hospital.
There is, indeed, much more that needs to be done on this front.
Indeed, more work is needed to identify the specific active ingredients, with a view of deciphering the mode(s) of action of the plant compounds.
Indeed, more research is needed to determine the effectiveness of resistive vibration exercise as a countermeasure, since the individual merits of resistance training versus vibration training could not be quantified in the present study.
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