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Indeed, modifications of residue 14 that enhanced internal hydrogen bonding increased potency of inhibition across all variants assayed in vitro.
Indeed modifications to chromatin are applied and removed in a highly specific fashion leading to the proposition of a histone code that is read by chromatin-associated factors [138].
Indeed, modifications of DNA methylation patterns can be inherited trans-generationally, through incomplete erasure of epigenetic patterning in the germline.
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Indeed, modification of cellular mRNA by nsp11 has been suggested previously [ 49].
Indeed, modification of the number of repeats of trinucleotide does not affect the reading frame.
Indeed, modification and remodeling cohort promoters are highly enriched with TF binding sites [ 37] compared with the other two cohorts.
Indeed, modification of calf thymus DNA CTT DNA) by 4– 6 results in a decrease of EtBr fluorescence intensity and increase in the relative viscosity of CT DNA in the same order 6 > 5 > 4, Figure 11d.
Indeed, modification of cysteinyl residues within ion channels is widespread [ 13– 17], and contributes both to pathological responses to oxidative stress [ 18] and to physiological signals, including nitric oxide [ 19], hydrogen peroxide [ 20] and oxygen [ 21], which generate reactive oxygen or nitrogen species (see references in [ 22]).
Indeed, most modifications are present substoichiometrically (occupancy below 50%), meaning that roughly equal numbers of substrate molecules lack the modification.
Indeed, three modifications are clearly seen: (1) The baseline progressively dropped with increasing irradiation time which has been previously explained by the PL quenching of the material (see Figure 14).
Indeed, these modifications reduced the occurrence of "mixed fragments" to negligible levels (less than 0.00025% of reads) in the CRoPS run reported here.
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