If one is to conclude that formaldehyde is a "known" human leukemogen, one must assert not only that these hypothesized modes of action are conceivably true but that it is indeed known that one of them is true, for otherwise an essential and utterly necessary element of the causal conclusion is missing.
It is indeed known that tortoises seek out plants with the highest water content (Peterson 1996).
It is indeed known that the alternative exon 8 present in the main ERbeta splice variants in humans (ERbeta2 ERbeta5) confers a conformational change in the second transactivation domain that alters the ability of the receptor to bind ligands and recruit cofactors [ 17].
It is indeed known that these island mice have adapted to a new diet (preference for earth worms, which are otherwise not much used by mice [ 52], i.e. the common mandible shape difference along PC2 could have been caused by positive selection.
Indeed, the oligarchs themselves know that it is in their interests to clean up their act if they want to tap foreign capital.
And indeed, the Alpha folks know that it's tough out there in the apps world, and it may not turn out to be used.
Or, indeed, with indifference making it known that it's no big deal.
Every mother knows that it indeed does take a village to raise a child.
Indeed, it is known that inadequate taxon sampling and systematic errors can override genuine phylogenetic signal, resulting in flawed phylogenetic reconstructions [ 40, 41].
Indeed, it is known that increase in Ca2+ level decreases glucose consumption presumably by inhibitory effect of Ca2+ on glycolytic enzymes and decreases mitochondrial ATP production by collapsing mitochondrial membrane potential.
