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As we know that T i, j (L, l) is the number of times that a transition from state i to state j is used in a Viterbi path ending in state l at sequence position L, we need to add 1 count for the transition from state l = i to the End state M = j at sequence position L. Note that this transition of state does not incur a change of sequence position as the End state is a silent state.
In addition, the delivery of fusion sequences of DNA coding for more than one antigen and adjuvants such as GM-CSF also increases the chances of incurring a therapeutic immune response.
Elevation works best when performed immediately after incurring a bruise.
In addition, forward-in-time simulators that store entire sequences incur a severe trade-off between the size of the genomic regions and the size of the populations simulated.
Soon-Shiong denied that the deal was designed to pump up GPS sales and said his company incurred a loss for doing the sequencing work for the university.
The basic idea with these studies is that if two proteins are coevolving and one incurs a mutational change in amino acid sequence, then the other will compensate with mutational change in sites that interact with the initial change.
However, in addition to this, we discovered that the At plasmid has incurred a large approximately 0.19 Mb deletion relative to the previously sequenced strain.
For example, in the B*57-restricted epitope KAFSPEVIPMF, the A163G CTL escape mutation incurs a fitness cost in vitro (A is found in 89% of sequences), a cost that could partially be restored by the S165N compensatory mutation [16].
Viral adaptation in the source sequence at a site in the HLA-B*08 immunodominant epitope likely to incur a fitness cost suggests that the source may have been an HLA-B*08+ individual.
We have also sequenced pools of 576 fish (1152 alleles) and were able to identify known variants but this incurred a 2-fold higher false positive rate to identify most of the known variants.
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