Though these policies are effective, they may be inflexible and unintelligent, which may incur false positive when controlling some legitimate apps.
The q-value for a particular correlation estimates the proportion, on average, of incurred false positives for correlations with a similar level of significance.
This approach identified 5 proteins passing the fold-change criteria, suggesting that such methods likely incur false-positives.
This is because DMRcate incurs false positives in regions flanking the ground truth when the kernel is too large, due to the support extending past ground truth bookends.
The Q-value of a test measures the proportion of false positives incurred (false discovery rate or FDR) when that particular test is called significant.
We re-express the generalized 1-0 loss function as follows for consistency with the subsequent sections: dI (θ < β thresh ) + k (1- d ) I (θ > β thresh ) Here k = c I I c I denotes the relative loss incurred by false negatives compared to that incurred by false positives.
If this does not hold, the sum can be weighted according to the penalties incurred for false positives and negatives, i.e. minimise θ × 1-Sensitivity) + (1 - θ )× 1-Sensitivity) where θ is the weight attached to the sensitivity.
The advantage of upper bound-based methods is that they do not incur a false positive error.
The TST alone strategy (£199,589 per 1000 contacts) had the lowest test costs (£15,433) but this strategy incurred the highest costs resulting from test inaccuracies (£70,081), particularly the costs incurred on false positive results (£55,090).
At this point, DMRcate likely incurs more false positives due to kernel support inferring false DM beyond the flanks of these very small true DMRs, as seen with the simulated data.
