Despite incremental progress, specific cause/effect linkages among the primary drivers of the pathology, (hemodynamic factors, inflammatory biochemical mediators, cellular effectors) and vascular occlusive phenotype remain lacking.
Thus, the first intervention incurs the full cost of the general campaign structure, and subsequent interventions require only the incremental costing specific to that disease.
Two sources of mortality were taken into account: the expected mortality from all causes given the age distribution of our sample based on CDC published estimates [ 44], and the incremental mortality specific to their cancer diagnosis and stage.
Two of the biggest challenges humanity has to face - promoting human health and halting environmental degradation are are strongly connected and too big to be addressed in an incremental, sector-specific way.
No traditionally relied-upon process exists, however applying an incremental, stakeholder-specific framework that mitigates perceived risks makes it easier to achieve bankability.
It was clear from many case studies that imaging platform technology is evolving rapidly, both through incremental platform-specific method development as well as step change improvements through novel optics and instrumentation.
Numerical implementation of constitutive laws involves specific incremental methods.
Analysts can start seeing the specific incremental business value from environmental and social strategies through this lens, and measure progress.
Contrary to popular wisdom, which too often employs the use of fear and dire warnings, it is far more effective to focus on bright spots and introduce small, specific, incremental changes at first to shape behavior.
Classical designs for physical experiments (DoE) have been developed to deal with noisy responses, while general space filling designs, though being usually effective for complete classes of problems, are not easily translated into adaptive incremental designs for specific problems.
