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Incremental probability of non-compliance after generic substitution was varied between 2.5% and 10%, while generic medication costs were assumed to be 40% lower.
Note that for this analysis, the incremental probability of becoming non-compliant after generic substitution is only applied to the three least intensive treatment settings.
In a separate analysis, the incremental probability of becoming non-compliant after generic substitution is also applied to the latter treatment settings.
Therefore, a logical next step may be to conduct a study that quantifies the incremental probability of becoming non-compliant after generic substitution.
As can be expected, the lower the price of generic risperidone, the higher the incremental probability of non-compliance must be in order for branded risperidone to be cost-effective or dominant.
If the incremental probability of non-compliance after generic substitution is 2.5%, 5.0%, 7.5% and 10% respectively, incremental effects of staying on branded risperidone are 0.004, 0.007, 0.011 and 0.015 Quality Adjusted Life Years (QALYs).
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The IS density functions for incremental probabilities of small leak and burst of individual defects are centred at the design points in the corresponding failure domains.
The IS density functions in the standard normal space for incremental probabilities of small leak and burst of the pipe segment over a short time period are established as the weighted averages of the IS density functions for small leak and burst, respectively, at individual corrosion defects.
There is no published literature that quantifies the effect of generic substitution on compliance in schizophrenia, therefore several incremental probabilities of becoming non-compliant after generic substitution within a reasonable range (0%100% with steps of 2.5%) have been explored.
As it is shown in Eq. 3, the treatment effect will then be the incremental probability impact caused by the coefficient of the interaction term (Ai and Norton 2003; Puhani 2012).
We term this incremental probability as systematic negative error.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com