When compared to the constant fitness case, incremental lineage expansion limits the importance of mutator pathways when two oncogenic mutations are required for cancer (C = 2) and to some extent at C = 3 with a low wild type mutation rate (kmut), but for higher values of C, α50% continues to be well within commonly observed ranges.
In the past few years, the performance of CPMUs has been brought closer to the physical limit; future incremental improvements will allow the limit to be reached.
These results suggested that epistasis among support genes could potentially limit incremental improvement of resource redistribution activity.
The incremental collapse (IC) limit was found to lie between 70% and 88% of the static collapse load for CFST columns.
LAM offered limited incremental diagnostic benefit over sputum-based diagnostics.
A symptom limited incremental protocol was performed on an electronically braked cycle ergometer (Corival V2, Lode BV, Netherlands).
It was speculated that since conventional chemotherapy showed excellent results for early-stage PGL, adding rituximab may only have added limited incremental value [ 29].
Another US study [ 39] found that among hospitals participating in a quality-improvement program, P4P had limited incremental impact on quality of care for acute myocardial infarction.
30 Although obesity is an independent CVD risk factor, it may go underappreciated that, in the presence of other proximal risk factors (eg, high blood pressure, hyperlipidemia, smoking), obesity adds limited incremental value to predicting incident CVD.
Recent findings have shown that different * 01 and * 04 subtypes appear to contribute equally to SE-smoking interactions in ACPA-positive RA [ 50], suggesting that analyses of specific SE subtypes may yield limited incremental information.
The latter method is more time consuming and is dependent on manipulations of workstation by the radiologist that can result in different divergent planes of four-chamber views and its incremental value is limited [ 16, 17].
