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We derived the CEAC from the joint distribution of incremental costs and incremental effects; we used non-parametric bootstrapping of the observed data to estimate these joint distributions.
We standardized the incremental effects we reported as "venous thromboembolism events avoided," "life-years or quality adjusted life-years gained' or 'deaths avoided per 1000 patients', as is commonly performed in venous thromboembolism literature.
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By giving incremental effects for different patient subgroups, we support comparative effectiveness research (CER) on osteoarthritis interventions.
By giving incremental effects for different patient subgroups, we support future comparative effectiveness research on osteoarthritis interventions and across countries.
Accordingly, we did not estimate the incremental effects of attaining additional modifiable lifestyle and risk factor goals in the patients we evaluated.
The results of the PSA are displayed as a scatterplot of incremental costs and incremental effects and as cost-effectiveness acceptability curves.
We believe that the components of the intervention may each have small, incremental effects that are both additive and synergistic, although we will not be able to determine the incremental effects of all individual components (see analysis plan below).
For each of these bootstrapped samples, the incremental costs, incremental effects, and the incremental cost-effectiveness ratio (ICER) will be calculated.
Incremental intervention costs were then divided by incremental effects to obtain incremental cost-effectiveness ratios (ICERs), which show the additional costs required to achieve an additional unit of effect when interventions are scaled up.
We estimated incremental marginal costs and incremental effects with the SUR (seemingly unrelated regression) model by using STATA.
Outcomes with their surrounding uncertainty are presented for IC, incremental effects (IE) and the incremental cost-effectiveness ratio (ICER).
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