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20 For each data set simulated, the incremental net benefit (INB) was computed using the relationship: INB=λ*ΔE ΔC, where λ is the CE threshold, ΔE, the mean incremental effect and ΔC the mean incremental cost.
These values were used to estimate the incremental effect, and when accompanied by estimates of the incremental cost, the ICER was estimated to range between $32,018HUI3I3) and $69,826 (SF-6D).
The strengths of the current study include use of validated theoretical and conceptual models, large sample size, inclusion of a broad range of neighborhood and community factors, entry of variables in blocks based on theoretical relationships to assess incremental effect, and focus on multiple self-care behaviors and outcomes.
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The results of the PSA are displayed as a scatterplot of incremental costs and incremental effects and as cost-effectiveness acceptability curves.
For each of these bootstrapped samples, the incremental costs, incremental effects, and the incremental cost-effectiveness ratio (ICER) will be calculated.
The results will be presented in an incremental cost-effectiveness plane in which the vertical axis will represent the incremental effects and the horizontal axis will show the incremental costs between the Short Stay Programme and care as usual before implementation.
These were presented graphically on a cost-effectiveness plane to show the estimated joint distribution of incremental costs against incremental effects and evaluated using net benefit analysis [ 15].
Incremental costs, incremental effects, and INB were calculated from the bootstrap sample.
Incremental effects and costs between groups will be modelled using generalized linear models.
A price reduction range of 20%60%% compared to the branded price is applied and incremental effects and costs are recorded.
Incremental effects and costs both have a linear relationship with the difference in compliance, as presented in Figure 1.
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