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The PBAC's expert reviewers evaluate whether any of the assumptions in the submission are unjustifiable and create simulations to assess the incremental cost-effective ratio (the additional cost for an additional beneficial effect, or Quality of Life Years ('QALY') gained)[ 22].
The results from other indications suggest that incremental cost-effective ratios (ICERs) do not differ significantly between Markov and DES models, but DES is able to report more outcome parameters.
The results indicate that the combination SAXA + MET produced a greater number of LYG and QALYs than that of SU + MET, with an incremental cost-effective ratio (ICER) equal to $7,3744.
ICER, incremental cost-effective ratio; QALY, quality-adjusted life year; nsNSAID, nonselective nonsteroidal anti-inflammatory drugs.
The results are reported as the incremental cost-effective ratio (ICER) over the 10-year period calculated using the model.
An incremental cost-effective ratio will compare the differences in costs with differences in gains in QALYs between the two interventions.
Similar(52)
A mean improvement in health in terms of QALYs of only 0.01 over a 12 month period would make the intervention highly cost-effective (incremental cost-effectiveness ratio of £464 per QALY).
One economic analysis of HBsAg screening of the general population (considering in the base case 35 year old males with a 2% prevalence) found this was cost-effective (incremental cost-effectiveness ratio (ICER) €23.966/quality adjusted life year (QALY)) [ 47].
The short-course strategy was found to be very cost-effective with incremental cost-effectiveness ratio of 1 4 US$ per life year saved.
The therapy was found to be highly cost-effective, with incremental cost-effectiveness ratio (ICER) of RM5,619 per QALY gained, equivalent to 18% of the country's per-capita gross domestic product.
Both liraglutide doses were cost-effective, with incremental cost-effectiveness ratios of £9449 and £16 501 per quality-adjusted life year gained vs. glimepiride, and £9851 and £10 465 per quality-adjusted life year gained vs. sitagliptin, respectively.
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