MCRI was calculated as the ratio of the insulin dose over the incremental area under the curve of insulin from 20 min to infinity (9).
In addition, we calculated HICISR as a ratio of the incremental area under the ISR curve (AUCISR 0 120 min) to the incremental area under the peripheral insulin concentration curve (AUCinsulin 0 120 min) (12).
Bezafibrate significantly suppressed postprandial elevation of triglyceride (incremental area under the curve (AUC): 544 ± 65 vs. 1158 ± 283 mg h/dl, p = 0.02) and remnant lipoprotein cholesterol (incremental AUC: 27.9 ± 3.5 vs. 72.3 ± 14.1 mg h/dl, p < 0.01).
The incremental area under the curve (AUCI) of insulin and glucagon levels during the first 5 min (AUCI-5) or the whole 15 min (AUCI-15) of the arginine test was calculated using the trapezoidal rule (19).
For the assessment of glycemic variability, we calculated the overall area under the IG curve (AUC) and the incremental area under the glucose curve of the test meal (incAUC) and assessed the mean IG, standard deviation (SD) of IG, and mean average glucose excursions (MAGE).
A sample size of 31 patients provided 80% power to detect a difference in glucose incremental area under the curve (iAUC) of ∼220 mmol × min/L between carbohydrate counting and the FII algorithm at the 5% significance level, assuming a within-person SD of differences in iAUC of ∼400 mmol × min/L.
The minimum clinically relevant difference between any two levels of treatment for incremental area under the curve (AUC) for serum glucose is taken to be 25% of the mean levels under standard diet conditions (8).
We first analyzed the determinants of postprandial triglycerides incremental area under the curve (iAUC).
The glycemic index (GI) describes the postmeal incremental area under the plasma glucose curve of carbohydrates in individual foods.
For each test food and individual subject, incremental area under the curves above baseline of blood glucose and plasma insulin concentrations was calculated.
Incremental area under the postprandial serum concentration curve (iAUC) of glucose, insulin, NEFA, TG and HDLc after the acute intake of both types of olive oil.
