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However, as successive generations of chemotherapy and anti-hormone therapy have improved the outcome, it becomes increasingly difficult to assess the value of breast screening compared with therapy.
Widening selection criteria are likely to lead to more MODY mutation carriers with mixed phenotypes, and in these case subjects, it will be increasingly difficult to assess the pathogenicity of novel mutations.
In addition, fertilizer prices are increasing due to high energy costs and because natural resources are limited and increasingly difficult to assess, as will be outlined in more detail below.
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It is "notoriously difficult" to assess this.
Ensuring quality is difficult to assess.
Bowling is generally more difficult to assess.
The quality was difficult to assess.
"How significant is difficult to assess".
Back complaints are notoriously difficult to assess.
Aldington's contribution is difficult to assess.
But such predictions are difficult to assess.
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