Apical cell-cell contact zones and actomyosin only later moved increasingly in concert, with no detectable change in actomyosin dynamics or cortical tension.
Importantly, somatic mosaic mutations are not always detectable in DNA from blood, although increasingly low levels of mosaicism can be detected through deep next-generation sequencing [ 76].
Interestingly, while Rta was detectable as early as 6 h and increasingly augmented until 48 h in the Dox-treated cells, Rta was only transiently upregulated at 24 h in the TPA/butyrate-treated cells.
Because early detection of pancreatic cancer is critical for patient survival, research is becoming increasingly focused on specific markers (subtle, identifiable cellular changes) that are detectable in precancerous pancreatic lesions.
From this change, further, there flowed certain cultural consequences; for, continuing the tendencies detectable even in the 1st century, the army was increasingly recruited from the most backward areas, above all, from the Danubian provinces.
Tracing the value chain reveals how land use decisions increasingly depend on the pressures and opportunities created by global markets, with detectable impacts on livelihoods and landscapes.
It is also expected that at nano-scale level there would be more anchored probe molecules and thus these would increasingly interact with target molecules which would result the strong or easily detectable signal.
These fibrillar collagens are detectable by second harmonic generation (SHG) microscopy, an optical imaging approach that is increasingly being used to provide diagnostic insights into cancer biology [ 9], and which has been used extensively in TACS analysis [ 5, 12, 19].
Other factors may operate in regulating detectable blood DC numbers, however, particularly within the bone marrow – in which it is increasingly recognised that functional maturation defects may exist for leukocyte lineages [ 63].
