Gene therapy is increasingly used experimentally and clinically to replace defective genes and/or impart new functions to cells and tissues.
Screening to determine defective MMR status is becoming increasingly common, especially with a view to identify families with Lynch syndrome.
Although defective brain insulin signaling is increasingly considered an important feature of AD pathology, the biological mechanisms of brain insulin resistance in AD have just recently started to be unraveled.
As the plaque adopts an increasingly inflammatory environment, M1 foam cells predominate and defective efferocytosis increases, with subsequent necrosis leading to the formation of the necrotic core.
Thus, as for NELF-A, the two kinase-defective Cdk9 mutants evoke the same increasingly pronounced responses with NELF-B as seen with wt Cdk9.
Ceasefire The international community is attempting to shore up an inherently defective government while trying to fight an increasingly effective enemy.
In CCR10-knockout mice, ILCs generated in skin-draining lymph nodes is defective in migration into the skin and increasingly diverted into spleens and other sites where CCR10 ligands are not expressed (Yang et al., 2016).
Defective translational control of protein expression is increasingly recognized as an important mechanism in the etiology of human diseases 1.
