It is increasingly appreciated that both clinical and biological features strongly influence outcome.
However, it is increasingly appreciated that inter-strain differences cannot be neglected in the experimental design.
It is increasingly appreciated that optimal nerve guides comprise both physical and molecular cues in support of peripheral axon regeneration.
In the periphery, it is increasingly appreciated that tolerance is a highly active process, with tolerogenic dendritic cells and regulatory T cells being the major players.
It is increasingly appreciated that the rates at which drugs associate with and dissociate from receptors — the binding kinetics — directly impact drug efficacy and safety.
It is increasingly appreciated that since cell and tissue functions are regulated by chemomechanical stimuli, precise control over such stimuli will improve the functionality of tissue models.
It has become increasingly appreciated that signals mediated by the lymphotoxin beta receptor (LTßR), a tumor necrosis factor (TNF) family receptor, mediate various outcomes in both the developing and adult immune systems.
Today it is increasingly appreciated that a diagnostic goldmine of LA biomarkers resides in the blood stream in complexed association with more abundant higher molecular weight carrier proteins such as albumin and immunoglobulins.
It has been increasingly appreciated that an intimate interaction between cells of the nervous and immune systems takes place in the gut, and may have a role in diverse inflammatory disorders.
Human geneticists increasingly appreciate that most complex traits that have a genetic component are influenced not by just a single locus, but by complicated gene-gene interactions [64].
It is increasingly appreciated that biological systems exploit glycosylation in synthesizing cell-surface glycans to organize plasma membrane receptors and control the recruitment of intracellular signal transduction mediators.
