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Inappropriate humidifier settings or selection of devices may negatively impact clinical outcomes by damaging airway mucosa, prolonging mechanical ventilation, or increasing work of breathing.
The effects of air velocity and work of adhesion on the dispersion ratio are shown in Fig. 4. The dispersion ratio increases with increasing air velocity, and decreases with increasing work of adhesion.
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Cardiopulmonary disorders unassociated with airflow obstruction can lead to reduced exercise capacity through mechanical factors and gas exchange abnormalities leading to increased work-of-breathing, increased work-of-the-heart and/or metabolic abnormalities.
These include increased work-of breathing due to mechanical changes in the lung, alveolar hypoventilation and gas exchange abnormalities, which increase the ventilatory requirements for any required VO2.
The increased work of breathing, rather than cardiac or muscular performance, is the limiting factor for hard physical work underwater.
Increased work of breathing.
Thus, infants with RDS have low lung volume, incompliant lungs, and increased work of breathing [73].
During pressure support ventilation (PSV), a mismatch between demand and assist could increase work of breathing and limit exercise.
The most common reason for initiation of NIPPV was hypoxemia (55.9%), followed by hypercapnea (25.4%), and increased work of breathing (8.5%) (Table 2).
Symptoms are primarily due to alveolar hypoventilation and an impaired respiratory gas exchange, with hypoxemia and hypercapnia resulting in increased work of breathing and clinical signs of dyspnea.
Swelling produces airway obstruction which, when significant, leads to dramatically increased work of breathing and the characteristic turbulent, noisy airflow known as stridor.
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