Sentence examples for increasing wild type from inspiring English sources
The analytical model (equations[11 13] in Methods) shows that the relative importance of mutator pathways Nrel 1∶0 increases with increasing wild type mutation rate kmut and increasing fold-increase in mutation rate, α, similar to the constant fitness case [15].
In essence, it is irrelevant if mutated or increased wild type TRPC6 is present in podocytes as they both can produce similar phenotypes.
In contrast to human lung cancer cells where genistein increased wild type but not mutated p53 [ 45], in colon cancer HT-29 cells we showed that genistein increased expression of mutated p53.
Structure-based functional studies indicate that FabC1 sterically blocks a structurally conserved surface of MntC, preventing its interaction with the MntB membrane importer and increasing wild-type S. aureus sensitivity to oxidative stress by more than 10-fold.
The first involves increasing wild-type p53 levels by interfering with the MDM2 mediated proteasomal degradation of p53.
This is more likely to occur when the absolute cost of hemizygosity is small (long pathways and weak selection), because increasing wild-type enzyme dose will have small effects on flux and small deleterious effects on fitness.
While BaP increased wild-type (wt) PD-L1 promoter-driven luciferase activity, deletion of one XRE-like element (5'-GCGTC-3') significantly attenuated this activity (Fig. 3a).
These results suggest that increased wild-type UCMK expression does not provide a significant enhancement in dFdC-mediated cytotoxicity and may warrant the implementation of studies aimed at engineering UCMK variants with improved activity toward gemcitabine monophosphate.
Therefore, even without sequence mutants, increased wild-type α-synuclein dosage may cause PD.
These results indicate that increased wild-type WNK4 in the kidney activates the OSR1/SPAK NCC signaling cascade and causes PHAII.
Taouil and colleagues showed that the long-acting salmeterol treatment increased wild-type CFTR expression in primary human airway epithelial cells.
