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Increasing white matter lesion burden on serial MRI scans has been associated with accelerated cognitive decline in several studies [8].
The correlations were positive, indicating increasing white matter deficit with increased (abnormal) binding.
In addition, studies in human adolescents have found an association between testosterone level and increasing white matter that is modulated by a functional polymorphism in the androgen receptor gene, the short arm polymorphism of which leads to more efficient androgen signalling than the long arm polymorphism.
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Failure to modulate activity was associated with increased white matter burden but not with increased amyloid burden.
Increased white matter (WM) volume suggestive of increased myelination was detected in the patient group treated with an atypical antipsychotic compared to a typical one.
In this case, the reduced cortical thickness may reflect increased white matter development in the KNOB region in relation to increasing motor skill development.
However, the MEG synchronization showed a rather diffuse pattern of increased functional connectivity extending beyond the areas where increased white matter volume has been observed.
In patients with hallucinations, a diffusion tensor imaging study [73] found increased white matter directionality in the arcuate fasciculus compared with controls or patients without hallucinations, these differences being most prominent in the left hemisphere.
These alterations include decreased gray matter volumes, increased white matter lesions, and reduced white matter integrity.
Underlying this left posterior insula region, we also found increased white matter in the left superior longitudinal fasciculus (SLF).
In patients, antipsychotics have been shown to increase white matter volume and intracortical myelin (Bartzokis et al., 2009).
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