Although the function of the NLRP3 inflammasome in myeloid immune cells has been well characterized, increasing evidence shows that the NLRP3 inflammasome activation also occurs in non-myeloid cells, namely hepatocytes, in normal and pathogenic states.
The biochemical mechanisms of action of MP have been well characterized: it increases extracellular levels of dopamine and norepinephrine by blocking the respective monoamine transporters[5].
Although many risk factors for dementia in the general population are well characterized, such as increasing age and co-morbidities (for example, alcoholism, stroke, and Parkinson's disease [ 13]), we still know very little about events associated with critical illness that may increase the risk.
Exercise is a very well characterized mechanism to increase blood lactate levels [12], and exercise has been demonstrated to play a protective role in AD [21].
Less well characterized is the increased risk of severe influenza pneumonia in obese patients.
The genetic contributions to bipolar disorder (BD) have been well characterized, with an increased risk, estimated to be 8-fold higher than the prevalence in the general population, in siblings with affected probands [ 1].
We show that kingdom-specific models such as FPfam can find instances of both novel and well characterized domains, increases overall coverage and detects more domains per sequence with typically higher bitscores than Pfam for the same domain families.
However, risk factor screening cannot improve screening effectiveness if factors that increase risk of exposure are not well characterized.
By using alkanes as swelling agents, we have been able to significantly increase the intra-particle mesopore size in previously well characterized UVM-7 materials.
However, the degree of this increased sensitivity to specific gastrointestinal infections is not well characterized.
The cardiometabolic risk conferred by increased visceral fat in HIV infection has been well characterized (6, 7).
