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The biological function of duplicate genes can be happenstance due to neutral stochastic forces, for increasing transcripts for high gene expression levels (e.g., rRNA), differentiation of function (e.g., globin genes) or to protect critical genes from mutational loss.
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Quantitative real-time reverse transcription PCR (qRT-PCR) analysis revealed increased transcripts for CHOP, spliced XBP1, and GADD34.
Reverse transcription-polymerase chain reaction and Taqman analysis from colonic tissue showed increased transcripts for interferon-γ and interleukin-10 from H. bilis-infected colitic mdr1a−/− mice.
Biochemical and molecular studies of PV patients have revealed no mutations in the Epo receptor, but granulocytes from PV patients have increased transcripts for the urokinase plasminogen activator receptor family member PRV-1 [8], whereas PV platelets show decreased expression of c-Mpl, the receptor for thrombopoietin [9].
IVIG responders had increased transcript abundance for genes associated with T and NK cells, while IVIG-resistant subjects had increased transcripts for genes association with neutrophil infiltration and apoptosis.
D. vulgaris biofilms had increased transcripts for the stress response proteins superoxide dismutase (sodB DVU2410), alkyl hydroperoxide reductase (ahpC DVU2247), msrB (DVU0576) and ahpC/TSA (thiol specific antioxidant) and an increase in protein levels for SodB (Table 4).
Thus, this locus may enhance the total amount of aliphatic glucosinolates by increasing transcript level for some of the biosynthetic genes.
Indeed, the minimal decrease in transcript abundance for a homolog of MAX2, involved in downstream strigolactone signaling through regulation of PIN1 [ 32] could account for the increased transcript abundance for PIN1 (Table 1).
In this case, increased transcript levels for thioredoxin and peroxidases were observed for both tolerant genotypes but mainly in M21, whereas in the susceptible line the up-regulation of these genes was rare.
The alternate splicing reduces transcripts for wild-type prelamin A and increases transcripts for a truncated prelamin A (progerin).
Novodvorska et al. (2013) detected increased transcript levels for genes encoding putative subunits of the respiratory chain mainly during the first hour of germination such as cytochrome b (An11g04370), which would supply energy for spore germination.
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