Sentence examples for increasing trail from inspiring English sources

Gp120 ligation of CXCR4 can also alter the sensitivity of immune cells to TRAIL induced apoptosis by increasing TRAIL R2 expression on CD4+ T cells [16], or on neutrophils [6].

Our studies provide direct evidence for increasing TRAIL sensitivity during colorectal carcinogenesis during the adenoma to carcinoma transition.

Hence, understanding the regulation of TRAIL receptor activation could provide insight into increasing TRAIL-induced apoptosis in these TRAIL-resistant cells.

Poorly differentiated areas in NSCLC showed a strong staining pattern for TRAIL [ 31] and in colorectal cancer an increased TRAIL expression within the tumour was associated with worse overall survival [ 32].

In contrast to the results reported here, Perlman and colleagues [ 27] were unable to detect elevation of TRAIL or TRAIL receptors in synovial fibroblasts but did observe increased TRAIL R3 in RA synovial fluid macrophages.

This might contribute to the increased TRAIL sensitivity of 090 cells; however, further studies will be required to determine whether TRAIL-R upregulation is necessary for TRAIL sensitisation by bortezomib.

"The park has just about reached the extent of its capacity, and over time, as the word spread, it could increase trail impact substantially," said Buzz Caverly, Baxter's director, who explained that he would rather see the trail bypass the park rather than go through it.

For example, overexpression of Akt increases TRAIL resistance [11], [14].

Inhibition of NFAT decreased TRAIL protein expression while overexpression of NFATc1 increased TRAIL promoter activity and increased TRAIL protein and mRNA expression.

Expression of NFATc1 activated TRAIL promoter activity and increased TRAIL mRNA and protein expression.

In addition, knockdown of NFATc1, NFATc2, NFATc3, and NFATc4 blocked PMA/Io increased TRAIL protein expression.