Exact(6)
From the survival analysis, we found that increasing the virulence score of a virus strain decreases the lifespan of the host.
Studies using a mouse model have suggested the role of bovine transferrin and lactoferrin in increasing the virulence of strain 2336 [ 65].
Furthermore, the T249P change in WNV-NS3 helicase has been suggested as increasing the virulence of WNV in birds in North America (15 ), although recent data do not support this hypothesis (8 ).
For example, warming seas are hypothesized to play a role in facilitating disease outbreaks by increasing the susceptibility of coral to disease through temperature stress and increasing the virulence of pathogens.
An interesting paradox occurs in the case of two bacteria that produce toxins generally regarded as factors increasing the virulence of the microbe : staphylococci that produce a so-called leukocidin, and pneumococci that produce a toxin called pneumolysin.
But they are thought to play a role in increasing the virulence capacity of H. pylori strains either directly or by encoding factors that could lead to variance in the clinical out come of the infection.
Similar(54)
Furthermore, dietary trehalose increases the virulence of a RT027 strain in a mouse model of infection.
In some instances, temperature increases the virulence of the disease itself, by prompting viruses to multiply more.
The study suggests that NASA and other space agencies may need to worry that long manned missions will increase the virulence of microorganisms that astronauts inevitably carry with them.
In a paper published last month in PLos Pathogens, researchers in the Bassler lab revealed the existence of a new quorum sensing molecule that increases the virulence of Pseudomonas aeruginosa.
Molecular biology postdoc Sampriti Mukherjee and professor Bonnie Bassler recently discovered a new quorum-sensing molecule that increases the virulence of one particularly nasty bacterium, Pseudomonas aeruginosa, which has become resistant to antibiotics.
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