A large, phase 4 study has shown that increasing the label-recommended weekly dose by 33% to 40 000 U wk−1 administered as a single injection produces a haematologic response after 16 weeks of therapy in 49% of patients (Gabrilove et al, 2001).
We found that this strong dependence in length of GRO is due to a bias that increases the labeling towards the 3' end of the transcript and we hypothesize that it is due to the downstream movement of RNA polymerases (see supplementary text S1 and supplemental Figure S1 for a detailed description).
Longer pulses of BrdU progressively increased the labeling of the GEPCOT cells.
In murine models, removal of a primary tumour increases the labelling index and angiogenesis of the distant micrometastases (Fisher et al, 1983; Folkman, 1990).
The addition of a high concentration of a radical scavenger such as 2,2,6,6-tetramethylpiperidine 2,2,6,6-tetramethylpiperidineincreased the labeling yield, perhaps by preventing the decomposition of the iodonium salt precursors before the fluorination reaction is complete.
For a future breakthrough of the method an increase of sensitivity by significantly increasing the metal labelling degree is demanded.
The Supplementary Material shows the high scoring read label rates (score ≥1) for four different environmental samples range from 10to60%0%, but relaxing the default minimum read label score threshold increases the read label rate to >50% in all cases.
Increasing the number of labels improves the selectivity of each label but raises the average arity of each node.
The fluorescence anisotropy value and the base-pair response dynamic range could be expanded by labeling the fluorophores in the middle of dsDNA and increasing the number of labels on dsDNA.
For a given level of carcinogenicity, FAA was more potent than DEN in causing loss of hepatic DNA and in increasing the parenchymal cell labelling index.
He pointed at the increasing competition the label faced from major record companies that came up with their own Latin divisions offering artists better promotion and distribution than was possible for an indie.
