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This effect may be mitigated by further increasing the administered activity or by increasing the acquisition time for heavier patients.
However, to achieve the same increase in NEC by increasing the administered activity, the NECR must be increased by 33% to 5.80 Mcounts/min.
However, increasing the administered activity has been shown to be less effective at improving image quality than the same proportional increase in acquisition time [5].
The current study also showed that the TFF was further improved (0.78) by increasing the administered activity concentration to 9 MBq/mL, but this difference was not statistically significant.
Figure 3 illustrates why increasing the administered activity is less effective at improving image quality than the same proportional increase in acquisition time, particularly for heavier patients for whom the NECR may already be approaching its peak value.
Optimization could be performed by either (1) reducing the absorbed dose to critical non-tumor tissues, and hence reduce detrimental side effects, in order to be able to increase the administered activity and thereby obtain better anti-tumor effects and/or (2) increase the therapeutic effects in tumor tissues without increasing the administered activity.
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This indicates a potential to increase the administered activity further for individual patients.
In a set of preliminary trials, we verified that the need to increase the administered intensities is also true for the two NMES protocols under investigation (data not shown).
87 Only after increasing the systemically administered dose of bumetanide by nearly two orders of magnitude, could brain concentrations in the range of the half maximal inhibition constant of NKCC1 be briefly reached.
Apparently, increasing the dose administered in two 50 μL injections did not result in higher numbers of PfSPZ getting from the skin to the circulation, invading and maturing in hepatocytes, eventually resulting in merozoites that invaded and multiplied in erythrocytes.
Both the AIS of the individual body regions (except AIS head) and the ISS increased with the administered volume (ISS: group 1: 26.8% and group 5: 33.2%; P ≤ 0.001; Table 1).
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