Sentence examples for increasing terminal differentiation from inspiring English sources
Sod2 deficiency also reduced the number of cells and thickness of the epidermis, while increasing terminal differentiation.
After three exposures, proliferation became confined to localized buds in the basal layer and increased terminal differentiation was observed (compact hyperkeratosis of the stratum corneum, elevated levels of K10 and filaggrin, and heightened transglutaminase activity).
This would explain why the epidermis of K14MycER transgenic mice displays both hyperproliferation and increased terminal differentiation.
Cellular senescence in SOD2 nullizygous mice with decreased proliferation and increased terminal differentiation of keratinocytes may result in the observed thinning of the epidermis.
Increased terminal differentiation and decreased proliferation due to senescent cells may collectively contribute to the decreased epidermal thickness in Sod2−/− mice.
PPARγ is an interesting target for cancer therapy as its expression is elevated in tumors and also because PPARγ activation is reported to result in decreased cell proliferation, decreased G0/G1 to S phase progression, apoptosis and increased terminal differentiation [ 25- 27].
Children with renal disease had highly variable and often markedly skewed maturation phenotypes, including CD4/CD8 ratio reversal, increased terminal effector differentiation in CD8+ T cells, reduction in the proportion of naïve T cells, evidence of T cell exhaustion and senescence, and variable loss of T cell CD28 expression.
ROCK1 depletion results in decreased keratinocyte adhesion to fibronectin and an increase in terminal differentiation.
One possibility is that melanin transfer decreases keratinocyte turnover and increases keratinocyte terminal differentiation.
The higher levels of Casp14mRNA suggest that an increase in terminal differentiation of keratinocytes occurs in the mutant skin.
Interestingly, Casp14 is also highly expressed in Hr tm1Cct/Hr tmicet mice, which display the hairless phenotype and show an increase in terminal differentiation of the epidermis with loss of function of Hr [ 7].
