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In accordance with recent findings, this may suggest that RGS4 variants impact on the functional integrity of the prefrontal cortex, thus increasing susceptibility for psychotic spectrum disorders.
This study demonstrates the significance of oestrogen for articular cartilage and subchondral bone and maintenance of healthy joints, supporting an etiological role for altered oestrogen signaling in osteoarthritis either by directly affecting cartilage or increasing susceptibility for an osteoarthritis trigger.
Membrane-bound CD55 was released from synovial tissue with phospholipase C. Functional consequences of CD55 expression were studied in the K/BxN serum transfer model of arthritis using mice that in addition to CD55 also lack FcγRIIB (CD32), increasing susceptibility for immune complex-mediated pathology.
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Increased gyrification in occipital regions might be related to increased susceptibility for cortical spreading depression.
An exceeded accumulation of surfactant phospholipids and proteins in the alveolar lining fluid impairs gas exchange and patients show increased susceptibility for microbial infections [22].
Increased biomechanical stress caused by different factors (weight, social rank, standing time) is a presumed effect that leads to an increased susceptibility for hoof diseases.
Our hypothesis was that altered frequencies of GST genotypes and environmental exposures might be associated with increased susceptibility for the development of esophageal cancer.
Diminished phagocytic capability was linked to increased susceptibility for (secondary) infection in rodent models whereas in humans, the direct influence of critical illness on phagocytosis is incompletely understood [49].
Because these pathways are mostly attributed to lung development and are normally thought to be quiescent in the adult lung, this raises the question of why these pathways become aberrant in the adult and whether pre- or postnatal insults impact developmental signal activity early on, thus contributing to an increased susceptibility for chronic lung diseases later in life [7, 18].
Our findings suggest that there may be some unknown factor -now or in the past- that counteracts the danger when you carry genetic features that may increase susceptibility for [Crohn disease and psoriasis].
While there he also started a new medical school, led many worldwide clinical trials to advance care for patients with heart disease, and spearheaded the discovery of multiple genes that increase susceptibility for heart attacks.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com