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In Uganda, there is evidence of increasing spread and establishment of new foci in central districts.
Lineage-2 (Beijing) strains are associated with increasing spread and drug resistance in some areas but not others (European Concerted Action on New Generation Genetic Markers, 2006), and with a lower (Click et al., 2012) or higher (Kong et al., 2007) proportion of extrapulmonary tuberculosis.
Since current pharmacological reagents are restricted by the increasing spread and evolution of resistance and/or their undesired side effects, and are often difficult to synthesize as the pure bioactive stereoisomer, investigations to explore novel drugs, or those that can act as templates for the development of new therapeutic agents appears imperative.
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These results demonstrate that vA34R gains an enhanced therapeutic index for PC via immune evasion, increased spread, and production of more progeny virus.
Subtype H9N2 viruses might have played a role in this increased spread and severity through an unknown mechanism.
For example, the globalisation of food production, trade and consumption has been associated with the increased spread and transmission of food born diseases [ 57, 58].
One possibility is that the increased transmissibility is a function of increased growth rate within the host and that this growth rate explains both increased spread and increased harm to the host.
These observations led us to hypothesize that tumor ascorbate levels could influence the activity of HIF-1, and affect tumor growth and aggression (defined by adverse pathology, increased spread and poor survival).
Overexpression of Tm5NM1 (a cytoskeletal Tm isoform) results in an increased number of stress fibers, increased spreading, and reduced cell migration velocity, compared to other Tm isoforms not typically associated with stress fibers.
Encapsulated fibroblasts showed increased spreading and proliferation when cultured in three-dimensions within hydrogels crosslinked using more rapidly degrading peptides.
In contrast, MECs on 2D spread and the corresponding F-actin and active myosin II were abundant both at the cell cortex and throughout the cytoplasm.. Increased spreading and F-actin in 2D conditions were confirmed by quantitative analysis of the cell-projected area and of the average fluorescence intensity of phalloidin staining per cell, respectively.
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