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Indeed, silencing miR-124a by almost 90% in H19-7 progenitors appeared to restore Stat3-signaling pathway in folate-deficient cells by increasing specifically the phosphorylation of Erk1/2 and Src kinases.
Conversely, the expression of the Stat3 regulator miR-124 was upregulated in deficiency conditions (≥65%), and its silencing by using siRNA partly restored Stat3 signaling in hippocampal neurons by increasing specifically the phosphorylation of Erk1/2 and Src kinases.
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Correspondingly, transcripts of a number of leukocyte-specific cell surface markers increased, specifically CD2, CD3D, CD7, CD8A, CD19, CD52, CD53, CCR6, and CCR7.
Therefore, whilst KPI-mRNA levels remained stable the KPI+species increased specifically in the AD brains.
Many amino acids increased specifically in LTH on recovery, implying that LTH may possess a rapid active renewal mechanism.
Tissue-specific accumulation under stress was also observed for three amino sugars (N-acetyl-glucosamine, N-acetyl-galactosamine and N-acetyl-mannosamine) which increased specifically in drought stressed shoots (up to 1.9-log2FC).
When physically touched by a male experimenter, women actually did get "hot and bothered" — their skin temperature increased, specifically in the face and chest.
Despite widespread concern about the wealth gap, however, the country is fairly evenly split when asked if taxes on the rich should be increased specifically for the purpose of redistribution of wealth, with a slim majority currently supporting.
(ii) p53 expression is increased specifically in GNPs.
The categorization accuracy increased, specifically for the equal-proportion and cooperators-rare condition.
To test this prediction, one has either to increase specifically the capacity of the cells to sense local density or increase the intrinsic noise in the cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com