Sentence examples for increasing small molecules from inspiring English sources

Increasing small molecules have been found to inhibit HIF-1 activity through various mechanisms including decrease of mRNA transcription, downregulation of protein synthesis, and disrupting HIF-1 stabilization, inhibition of subunit heterodimerization, interference of HIF-1-DNA binding, and transcriptional activity attenuation of HIF-1 [ 91, 92].

It has been established that increasing small molecule lipophilicity enhances cellular uptake.

ChEBI is currently undergoing a period of restructuring which will allow it to incorporate the small molecule structures from (and link to) EBI's new chemogenomics database ChEMBL [2], increasing its small molecules coverage to over 500,000 entities.

Plasma apoB concentration provides a measure of the concentration of all potentially atherogenic particles (Each very low density lipoprotein, intermediate-density lipoprotein, and LDL particle is covered by 1 apoB molecule), and increased small dense LDL particles is related with IR and CVD risk.

An increasing number of small molecules with different structures have been discovered that bind to RNA.

Despite that an increasing number of small molecules has been reported to possess excellent G4 stabilizing properties, none of them has progressed through the drug-development pipeline due to their poor drug-like properties.

With increasing availability of small molecules that target different classes of chromatin modifiers, identification of epigenetic enzymes responsive to septic signals will be an important translational goal to elucidate key molecular mechanisms underlying the pathogenesis of clinical sepsis.

The endothelium requires more dynamic and heterogeneous cell junctions in order to coordinate fast and local permeability increases to small molecules and cells from the bloodstream.

The suggestion that permeability might have been increased for smaller molecules than albumin can be ruled out for the same reason.

Heterologous expression of novel combinations of enzymes promises to provide new or improved synthetic routes towards a substantially increased diversity of small molecules.

Computational approaches based on orthology mapping seem to be the most intuitive and therefore successful methods to increase coverage on small molecules in databases for all taxonomic species.