The terminal sequence motifs can be processed by posttranslational modifications, thereby providing a means to increase sequence diversity and to regulate interactions.
Local anomalous DNA conformation attributable to the Alu-Yi6 element, as suggested by enhanced DNase I sensitivity and obstruction to DNA sequencing, could be a contributing factor of the increased sequence diversity.
It is possible that the increased sequence diversity in the early epidemic was somehow related to non-neutral drift during that period, perhaps across larger populations than we have investigated.
In addition, pathway analysis of non-synonymous variations revealed increased sequence diversity in the putative virulence genes of SSTI isolates.
The sequencing libraries generated from the lesion bypass products were then mixed with an equal molar amount of bacteriophage ΦX sequencing libraries to increase sequence diversity.
All methods tested for the impact of sequence divergence on catalytic residue prediction INTREPID, Global-JS and Rate4Site benefit from increased sequence diversity (see Supplementary Materials).
Unlike the 17q21.31 inversion, we did not find strong evidence of extended linkage disequilibrium or increased sequence diversity for the other inversion loci.
The results obtained from fraction 10 again indicate that the increased sequence diversity with the DC diet relative to the HP and HC diets was most likely due to the more versatile nutrient composition.
We selected barcodes containing as few "G"s as possible in order to avoid barcode biases caused by strand invasion [ 9], and pooled six different libraries to increase sequence diversity and address the low mappability observed in experiment 2. The linker was removed in order to evaluate whether using Illumina-recommended barcodes would improve read mappability.
Moreover, higher mutation rates prohibit the evolution of the U-parasite also through increasing the sequence diversity of the A-catalyst, which makes it difficult to parasitize the A-catalyst (Fig. 3; see also [ 7, 19]).
Compared to other bacteria, the genome of Mycobacterium tuberculosis is stable and genetic variation was thought to be limited, but with increased sequencing, greater diversity has been recognized (Homolka et al., 2010).
