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In order to enrich VHH phage clones of increasing selectivity for OTA, the bound phages were eluted by glycine hydrochloride in the first two cycles of panning.
To address this, site-directed or random mutagenesis of the region around the QB binding pocket in PSII has been carried out with a view to increasing selectivity for individual triazine herbicides (Rea et al., 2009; Lambreva et al., 2013).
The sequential arrangement of three thresholding nonlinearities glutamate release from bipolar cells, glutamate release from VG3-ACs, and spike generation in W3-RGCs likely further contributes to the increasing selectivity for narroW3-RGCs likelyes and difurtherial contributeslobal toxthee motincreasingceselectivitys oforhe OMS circuit.
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Rigid bridges such as those provided by bispidine are discussed in terms of increased log K1 values, and sharply increased selectivity for smaller metal ions.
It also opens the possibility for high-throughput screening of enzymes with increased selectivity for NADH.
Compounds with increased selectivity for it may provide significant activity and fewer side effects.
In general compounds with bulkier side chains displayed increased selectivity for nNOS over eNOS and iNOS isoforms.
Biochar may facilitate mycorrhizal colonization of the plant roots [111], thus causing increased selectivity for P in the mediated P uptake pathway.
Second generation tau tracers are now just appearing with [18F]GTP1 [18F]RO6958948958948 [40] and [18F]MK6240 [41] all demonstrating cleaner signals with increased selectivity for tau.
Rational and structure-guided ligand-design techniques are employed for creating 'biomimetic dyes' mimicking natural biological ligands, thus displaying increased selectivity for targeted proteins.
While the first derivative LDN-193189 exhibited pan inhibition of BMP receptors, the more recent compound LDN-212854 has shown increased selectivity for ALK2.
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