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Another possibility involves strong truncating selection with gradually increasing selective pressure – in this case all haplotypes that can withstand a given concentration will have equal fitness at that concentration regardless of their ability to withstand higher concentrations.
We applied the synthetic system to evolve the virus with increasing selective pressure in environment, specifically to evolve a virus-carried heterogeneous gene (luxR), which consequently enhances the ability of infected hosts to survive against antibiotics.
As a mitochondrial mutation causing the SC spreads within the population, there is increasing selective pressure to resolve the SC.
Only recently, a study performed in a large mildly selected cattle population from Western Africa under an extensive breeding system has shown that LD extends over shorter distances than the previous studies from developed countries, which was explained by increasing selective pressure and/or by an admixture process (Thevenon et al. 2007).
Discharges of chemical agents (drugs, disinfectants, heavy metals, and other pollutants) into the environment can accelerate the lateral movement of resistance genes across bacterial populations by increasing selective pressure for maintenance of mobile genetic elements (MGEs) (4 ) or by increasing the rate of gene transfer (5 ).
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Spore dispersal would impart increasing selective pressures on fungi to synthesize an arsenal of polyketide derivatives to facilitate the colonization of diverse and sometimes hostile environments.
Until recently, vancomycin was believed to have retained activity against all strains of S. aureus; therefore, the spread of MRSA has led to increased vancomycin usage and hence increased selective pressure for the development of resistance [ 5].
At the boundary of the first exon, FitCons2 scores spike, indicating increased selective pressure at both intronic (14, ρ = 0.92) and exonic (04, ρ = 0.93) splice boundaries.
These results indicate that the differences in Ka values observed between the groups of ubiquitously and differentially expressed PKs are not caused by regional variations in the neutral mutation rate and reflect increased selective pressure on amino acid sequences.
Increased mutation rates in a tightly constrained area of a genome can be a marker of increased selective pressure.
Hence high prescription rates of macrolides are questionable and likely to unnecessarily increase selective pressure on bacterial pathogens.
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