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Moreover, simulation results showed that increasing ring height and decreasing its thickness increases its sensitivity and decreases its stiffness.
It was found that the temperature where dehydrogenation of hydroaromatics became favorable over hydrogenation reactions decreased with increasing ring size.
The ring strain was observed to increase with increasing ring size for the three lactones studied increasing the thermodynamic scope for these monomers to polymerize.
Under the electrokinetic and bacteria conditions, the relative enhancement in the degradation of four- to six-ring PAHs compared to the control experiment was much stronger and increased with increasing ring number.
The data indicate that the increasing ring condensation in asphaltenes and resins is associated with an increase in both the degree of alkyl substitution and alkyl branching on the aromatic ring and not with the alkyl side chain elongation.
The model has learnt the RDKit canonicalized SMILES format of increasing ring numbers, and expects the first ring to be numbered "1".
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Fabbro, M., Rodriguez, J. A., Baer, R. & Henderson, B. R. BARD1 induces BRCA1 intranuclear foci formation by increasing RING-dependent BRCA1 nuclear import and inhibiting BRCA1 nuclear export.
A series of new analogues of DOX has been synthesised, in which the amino group in the daunosamine moiety was replaced by a formamidine system containing the rest of the cyclic secondary amine with gradually increased ring size.
Grubbs has reported replacing a phosphine ligand (PCy3) with an imidazol-2-ylidene in the olefin metathesis catalyst RuCl2 PCy3)2CHPh, and noted increased ring closing metathesis as well as exhibiting "a remarkable air and water stability".
In addition to altering ring size by increasing the length of the side chain via hCys substitution, we also increased ring size by lengthening the backbone between Cys1 and Cys2 by the insertion of two alanine residues (enzyme 11 in Table 4) reported by us previously.
More generally, the preference for ring-fused systems to undergo semipinacol rearrangement rather than Appel reactions can, therefore, be ascribed to a combination of factors: the slower SN2 reaction at a secondary rather than a primary alcohol, the enforcement of a favourable orbital alignment for bond migration, and increased ring strain offering a greater driving force for rearrangement.
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CEO of Professional Science Editing for Scientists @ prosciediting.com