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The Adjuvant! model forecasted a broad range of local therapy recurrence and mortality estimates, displayed by increasing recurrence risk in the second column of Table 1.
Increased expression of IAP, (leading to reduced apoptosis) may explain the effect of COX-2 in increasing recurrence of DCIS after surgical treatment.
All methods are stable in front of censoring, worsen with increasing recurrence levels and share a bias problem which, among other consequences, makes asymptotic normal confidence intervals not fully reliable, although they are well developed theoretically.
Often genetic diagnosis is delayed, exposing the patient to unnecessary investigations and treatments, precluding the full benefit of a targeted approach to treatment, and increasing recurrence risk in the families.
Chemotherapy was more often prescribed in the case of tumours of increasing grade (<0.001, X), increasing size (p = 0.012, Mann–Whitney) and increasing recurrence score (p < 0.001, Mann–Whitney).
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Supporting evidence indicates that increasing recurrence-free survival is associated with higher ER expression even in patients who did not receive any adjuvant treatment [ 25].
This can lead to incomplete tumor resection and thus increased recurrence rates.
When compared to index procedures, increased recurrence rates and poorer outcomes can be expected after revision surgery [20, 49].
Leukemia stem cells (LSCs) account for the development of drug resistance and increased recurrence rate in acute myeloid leukemia (AML) patients.
To identify cutoff values of markers that correlate with the histopathologic diagnosis of ameloblastic carcinoma (AC) and/or the increased recurrence potential of ameloblastoma (AB).
Such studies, when designed, analyzed, and interpreted correctly, can help distinguish genetic from environmental causes that portend increased recurrence of a particular pregnancy complication (eg, recurrence of gestational diabetes) or a perinatal outcome (eg, recurrence of preterm birth or preeclampsia).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com