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At our centres, the indications for bone scan examinations in prostate cancer patients are mainly PSA in blood >20 and/or high GS (>8), increasing PSA values (biochemical progression) and bone pain (symptomatic progression).
At 10 years of follow-up, approximately 35% of men treated with RP and 50% of men treated with EBRT will develop biochemical recurrence [6], defined as two consecutive increasing PSA values >0.2 ng/mL after RP and >2 ng/mL above the nadir after EBRT [7].
This method allows more accurate and complete prostate sampling at subsequent re-biopsy when the first biopsy is negative but the patient continues to have increasing PSA values.
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However, no significant changes in PSA kinetics were observed in any patients and increased PSA-specific T cell reactivity was only observed in patients in the highest dose cohorts (4 of 15) [47].
Interestingly, we show for the first time that fluoxetine tended to increase PSA-NCAM immunoreactivity in adolescent rats.
Using only evaluable PSA values, PSA-DT was calculated using an algorithm calculator (http://mskcc.org/applications/nomograms/prostate/PsaDoublingTime.aspx).aspx
Sensitivity for detection of recurrence was 95.7 % for PSA-values ≥ 2ng/ml, 81.4 % for PSA-values of 1-2 ng/ml, 76% for PSA-values 0.5-1 ng/ml, and 51% for PSA values ≤ 0.5 ng/ml.
PSA values used to calculate the PSA-DT were evaluated by a study-independent, blinded reviewer.
Thus, PET/CT should not, theoretically, primarily benefit patients with high PSA values, but rather those with low PSAs [21].
Even though the literature sets the positivity of 68Ga-PSMA PET/CT dependent on the PSA-value (PSA < 0.5), in this study only 6 patients have PSA-values < 0.5 ng/mL, and 27 patients have PSA > 1 ng/mL (Table 1).
The plot of Area vs. Concentration in Figure 3 for the light peptide group of one typical peptide bi0161 (PSA-IVG) shows that for Area the variance increases with increasing mean value.
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