Nevertheless, our results still are an indication that the increased correlation of SURtc with K slope compared to SUV translates into an increased prognostic value.
Clinical decision rules that take advantage of the change in SOFA over time have increased prognostic value over models that use a single SOFA measurement.
Second, combining information from self-report and performance measures has been shown to increase prognostic value, particularly in high-functioning older adults [ 10].
Changes of galectin-3 levels after 6 months did not add prognostic information to the base-line value (n = 291); however, combining plasma galectin-3 and BNP levels increased prognostic value over either biomarker alone (RoC analysis, P < 0.05).
In addition, scoring models that take advantage of a score's change over time may have increased prognostic value over models that use only a single set of physiologic measurements.
Finally, we found that clinical decision rules that take advantage of the change in SOFA score over time have increased prognostic value over models that use a single SOFA measurement.
Computer-assisted analysis of histological appearance has been reported to increase prognostic value but it still relies on morphological changes to predict behaviour of the lesion (Guillaud et al, 2008).
In reclassification analyses, the four biomarkers added on top of SOFA score, CRP, and WBC showed increased prognostic values than SOFA score, CRP, and WBC alone.
Allred score system evaluates a combination of intensity and proportion, potentially increasing the prognostic value of the analysis by the intensity alone or the proportion alone in this study.
Our findings support the recent ideas of using a 'multimarker' approach, i.e. measuring multiple plasma proteins in instead of single biomarkers or only BMI to increase the prognostic value for individual disease risk [8], [40], [41].
