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However, with increasing potency and localization in radionuclide therapy comes the need for increased certainty about the quantitative biodistribution of the therapeutic radiopharmaceutical as well as more sophisticated methods for understanding and quantifying radiation effects at a microscopic level, i.e., radiation microdosimetry [15].
New steroidal-based compounds are currently being developed with the objective of increasing potency and oral bioavailability.
In particular, the data presented in this study suggest that the supply of opiates and cannabis, in particular, have increased, given the increasing potency and decreasing prices of these illegal commodities.
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Narwal, M. et al. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.
Nevertheless, variations of scaffold and peripheral areas can increase potency and pharmacokinetic profile of drug candidates.
A molecular fragment of this natural product derivative can provide new inhibitors with increased potency and selectivity.
Efficacious substituents were identified and used to design new HIV inhibitors with increased potency and lower cytotoxicity.
In addition to particle size, federal experts are investigating whether the anthrax powders have electrostatic charges that affect dispersal and chemical coatings meant to increase potency and shelf life.
They were also told that the incidence of new schizophrenia cases reported to GPs had gone down, not up, between 1998 and 2005, indicating a weak link between increased potency and use in the past two decades and mental health problems.
Using SAR techniques, several analogues of cryptolepine were designed to increase potency and to broaden the antifungal spectrum over several opportunistic microorganisms.
These experiments place an important constraint on the design of sulfoximine libraries for screening experiments to obtain ASNS inhibitors with increased potency and bioavailability.
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