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Antigen-sparing vaccines are a means of increasing population coverage at the price of reduced efficacy.
The vaccine stockpile can also be increased to model the effects of increasing population coverage, as done for the simulations in Figure 4.
The CPRD has evolved over time, with increasing population coverage and, through linkages with secondary care data and laboratory data, provides access to more complete data sets.
When implemented by strong international NGOs with adequate funding, Care Groups have been remarkably effective in increasing population coverage of key child survival interventions.
In the long term, increasing population coverage with improved drinking water sources and proper sanitation are the most effective means of preventing outbreaks of cholera and other enteric diseases (5 ).
Further, the assumption that the number of provinces expands with increasing population coverage may not accurately reflect how a country implements health interventions, and analysts should adjust their assumptions accordingly.
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Thus, this vaccine concept may cope with HIV genetic variability by increasing breadth, as well as providing increased population coverage.
Provision of ITNs through health facilities, communities and the private sector has increased population coverage in Malawi [8], but the impact of increased coverage on malaria in pregnancy has not been widely studied.
By virtue of inducing broad responses against conserved CD4+ T cell epitopes that can be recognized in the context of widely diverse, common HLA class II alleles, this vaccine concept may cope both with HIV genetic variability and increased population coverage.
Antigen-sparing vaccines have the most potential to increase population coverage but may be less efficacious.
Rather, our experience was an increase in the intensity of intervention in the same areas to increase population coverage.
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