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Combining mothers and children to improve precision yields a similar pattern of increasing point estimates with increasing age, with the oldest age combination (15-year-old children and middle aged mothers) giving an SNP heritability estimate of 0.37 (s.e. 0.25, P = 6.6 × 10−5) for the familial component of AA (Fig. 6).
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Thus, multiple comparisons may explain the slightly increased point estimates observed in some exposure categories.
They found increased point estimates for tubular cancer with estrogen alone and past use of estrogen-progestin, but the power was low.
For site specific serious infections, we found increased point estimates for sepsis, urological or gynaecological infections, and skin and soft tissue infections; these analyses should, however, be interpreted cautiously because of limited power.
Longer duration heat waves numerically increased point estimates of associations (i.e., closer to the null for negative associations and further from the null for positive associations) with health outcomes for 10 of 15 HIs examined in PTB duration models and 7 of 15 HIs examined in NAD duration models (see Supplemental Material, Figure S2).
In analyses based on our primary analytic model with no exclusion of BRAF-mutated cases, including all cases with unknown KRAS-mutation status as KRAS-mutated cases increased point estimates to HR=1.53 (95% CI: 1.13 1.79) for disease-specific survival and HR=1.39 (95% CI: 1.23 1.57) for overall survival.
Our data were too few to allow further evaluation of the fact that there was a consistent finding of an increased point estimate for tap water in the adjusted analyses.
For example, we estimate that the average effect of a 10-ppb mean increase in mean quarterly 1-hr maximum O3 over the 18-year median of 87.7 ppb was a 4.6% increase (point estimate) in quarterly hospital discharges for asthma (increase from 3.12 to 3.26 × 10−4 age-eligible population) over a time period in which the median age-eligible population was approximately 4 million persons.
In addition, the generally increased point risk estimates combined with a limited statistical power indicate a need for studies with very large sample sizes that can allow for detailed stratification of the analyses.
29 This replacement marginally goes in the direction of increasing the point estimates of the marginal effect of the Fox News dummy (i.e., reducing its absolute value) and decreasing the one on the CNN dummy (i.e., increasing its absolute value).
Adjusted risk estimates would increase both point estimates and the upper end of the 95% CI.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com