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Escalating doses induced an increasing number of transcripts with 30, 69 and 137 genes differentially modified at 0.5, 1.0 and 1.5 Gy respectively.
Representing the transcripts and their relation to each other has become extremely complicated due to the increasing number of transcripts for each gene.
A summary of the information held currently in the database, based on EnsEMBL release 40, can be found in Figure 2. Figure 2a shows that with an increasing number of transcripts per gene it can sometimes be difficult to find unique regions at the gene level since the proportion of overlapping regions between all transcripts decreases, in some cases totally.
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This is because an increasing number of transcript isoforms are being discovered, thus changing many of the previously recognized "CSEs" to ASEs.
The steadily increasing number of transcript annotations for a single gene reflects the continuous progress in the development of ASI prediction algorithms.
Indeed, the MIPS and the TIGR have made available a new annotation release each year taking into account the completion of the genome sequence, the improvement of gene prediction tools and the increasing number of transcript sequences in the database [ 3].
Increasing numbers of transcripts have been reported to transmit both protein-coding and regulatory information.
> We evaluated the scalability of FastMap with increasing numbers of transcripts and SNPs using the hypothalamus dataset.
In the case of both SMM and HAM, computation time for FastMap scales linearly with increasing numbers of transcripts (Fig. 3a).
Comparatively, we observed increased number of transcripts in the blood fed salivary glands (130 transcripts) as compared to sugar fed mosquitoes (74 transcripts).
Summing up, a significantly increased number of transcripts involved in cell wall modification and cell-cell signalling, together with genes regulating the restriction of cell division and auxin transport were detected in the pool of 313 transcripts enriched in small, adaxial Iberis petals.
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