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To process these enormous amounts of data, advances in the field of high-throughput screening complement the previously mentioned methods in a way that an increasing number of compounds can be screened against desired biological targets with a decreasing financial effort [3].
We detect an increasing number of compounds as technical methods become more sensitive, so finding structure among the two dozen or more compounds detected has often relied on statistical analyses using multivariate methods such as Principal Components Analysis[24].
DNA topoisomerase inhibitors represent a main class of anti-cancer drugs with an increasing number of compounds which are nowadays in clinical use.
This suggests that further research is needed on the optimisation of treatment strategies in this era, when an increasing number of compounds became available for the treatment of patients with this chronic disease.
An increasing number of compounds have been isolated from different endophytic fungi for example, fumitremorgins B has been isolated from Phomopsis sp. and periconicins A and B have been isolated from Periconia sp[ 9, 10].
An increasing number of compounds with antibacterial activity are being isolated from endophytic fungi, including fumitremorgins B isolated from Phomopsis sp., and periconicins A and B from Periconia sp. [ 2, 3].
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By the first decades of the 19th century, the nascent sub-discipline of organic chemistry began identifying and synthesizing ever increasing numbers of compounds (Klein, 2003).
Increasing numbers of compounds, previously classified as antagonists, were shown to inhibit this spontaneous or constitutive receptor activity, instead of leave it unaffected as expected for a formal antagonist.
Increasing numbers of compounds extracted from traditional Chinese medicine (TCM) have been indicated as potential lead compounds against cancers [ 26– 28], inflammation [ 29], influenza [ 30], viral infection [ 31], metabolic syndrome [ 32], diabetes [ 33], stroke [ 34– 36], and many other diseases [ 37– 41].
New lab techniques, increased numbers of compounds to screen, and expanding toxicology and environmental programmes are other reasons for companies to hire extra scientists.
In addition, there are an increasing number of synthetic compounds (SERMs) or naturally occurring compounds (phytoestrogens) that exhibit agonist or antagonist estrogenic properties, depending on the tissue.
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