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Decreasing threat predictability also led to increasing neural activity in the orbitofrontal and dorsolateral prefrontal cortex at mid-latency stages.
Similarly, increasing neural activity decreased the transcriptional level of lola.
As shown by a comparison with mean activity immediately after cue offset (Fig. 3 B, immediate postcue period), this result reflects increasing neural activity across the postcue delay, not a sensory aftereffect of the cue stimulus.
Correlations with spelling-to-sound consistency (number of friends minus number of enemies) were all in the negative direction, indicating increasing neural activity for words with more enemies than friends.
A cohort competition effect, reflecting variations in initial cohort size, was found mainly in bilateral BA 47 (pars orbitalis and orbital frontal cortex), extending into L BA 45 (pars triangularis), with increasing neural activity for larger cohorts with more word candidates.
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BOLD contrast fMRI is not only dependent on increased oxygen metabolism due to increased neural activity since activation-related differences also depend on changes in cerebral blood flow (CBF) and cerebral blood volume [Buxton, 2012; Davis et al., 1998; Hoge et al., 1999].
Zhuang et al. (2014) suggested a division of labor within the left IFG: Cohort size (the number of competitors sharing phonemes from word onset that are activated in parallel) increased neural activity in bilateral BA47, whereas cohort selection (reduction of competitors due to accumulation of acoustic information) focuses in left BA44.
The middle frontal gyri, in which we detected increased neural activity in our subjects with pre-manifest Huntington's disease, are often activated in tasks requiring executive functions, such as response inhibition (Blasi et al., 2006) and attentional control (Corbetta and Shulman, 2002).
"It is possible that increased blood flow might result in increased neural activity and function, opening new therapeutic strategies for treating age-related neurodegenerative conditions," the authors wrote in the journal Science.
Brain aging has been associated with both reduced and increased neural activity during task execution.
The main factor TOM led to increased neural activity in the anterior cingulate cortex and left temporopolar cortex.
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