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To examine whether increasing mean arterial pressure (MAP) with the administration of phenylephrine would improve internal jugular venous oxygen saturation (SjvO2) during normothermic cardiopulmonary bypass (CPB) in patients with preexisting stroke.
Results Treating rats with an EPA/DHA bolus before reperfusion significantly improved the ischemia reperfusion syndrome, increasing mean arterial pressure (151 ± 13 vs 122 ± 17 mmHg, p < 0.05), coronary and carotid blood flow, and decreasing infarct size (39.9 ± 2.3 versus 26.8 ± 5.7%% of left ventricle, p < 0.05).
Increasing mean arterial pressure from 65 mmHg to normal levels is associated with improved microcirculation in hypertensive septic shock patients.
The aim of this study was to measure the effects of increasing mean arterial pressure (MAP) on systemic oxygen metabolism and regional tissue perfusion in septic shock.
For instance, in patients with septic shock, artificially increasing mean arterial pressure beyond ~65 mmHg does not improve established variables of tissue perfusion (LeDoux et al. 2000).
Increasing mean arterial pressure by norepinephrine during septic shock can increase cardiac output and improve microvascular flow and reactivity in stable resuscitated patients without modification of global oxygen consumption.
Similar(47)
When they ate and slept about 12 hours out of phase from their habitual times, they showed decreased leptin levels, increased glucose (despite increased insulin), and increased mean arterial pressure.
Norepinephrine is used to increase mean arterial pressure during cardiopulmonary bypass.
Intravenous phenylephrine was administered to increase mean arterial pressure by 20%.
Results: Bilateral carotid occlusion (BCO) increased mean arterial blood pressure from 46±7 mm Hg to 53±8 mm Hg (mean±S.D).
Conclusion: There was no acute intraoperative improvement of hemodynamics except increased mean arterial pressure with biventricular pacing.
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