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Intra-arterial (IA) delivery of chemotherapeutic agents has the obvious effect of increasing local dose and reducing systemic levels.
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Direct trauma to adjacent bowel from perforation is uncommon but increased local dose can lead to long term fistula and stricture formation [21].
Other studies have employed three exposures of 12 20 Gy in treatment of a large variety of human cancers (the hypofractionated approach), demonstrating increasing local control rates as the dose per fraction escalated[32].
Those absorb more energy per unit mass than soft tissue increasing the local dose deposited in the tumour (Hubbell and Seltzer 1996).
Increasing the local dose of contrast medium would theoretically result in higher enhancements in these structures.
Thus, increasing the local dose of radiation for patients with suprastructural involvement is expected to result in better local disease control.
Recent interest has been developed to create non-uniformity within the targets, more specifically to increase the dose to certain tumour subregions in order to increase local control (so-called dose-painting).
The addition of a boost dose increases local relapse-free survival [ 4].
For example, xenon spallation gas products are believed to have deposited on a downstream gold amalgamation bed designed to remove mercury vapor and this disposition increased the local dose rate.
To evaluate whether intraoperative high-dose remifentanil infusion increased local anesthetic consumption in postoperative epidural analgesia and postoperative pain scores compared with low-dose remifentanil infusion.
Vaccinations were well tolerated without increased local reactogenicity as a consequence of increased antigen dose or booster dosing.
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CEO of Professional Science Editing for Scientists @ prosciediting.com