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Murray added that, since 2011 when the study ended, cannabis has generally been increasing in potency, with synthetic varieties such as "Spice" having been linked to acute episodes of psychosis.
The anticonvulsant drug lamotrigine displayed the largest change in minimum inhibitory concentration (MIC) upon temperature downshift, increasing in potency more than 50-fold from >512 μM at 37°C to 7.8 μM at 15°C.
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This torrent of data, however, is the result of the second technological change that is driving genomics, in the power of DNA sequencing.The new lawComputing has, famously, increased in potency according to Moore's law.
We could also monitor drugs that increased in potency throughout the time course.
Many drugs increased in potency over the time course, which was easily determined using the real-time cell viability assay.
"Redesign of a cross-reactive antibody to dengue virus with broad-spectrum activity and increased in vivo potency". Proc Natl Acad Sci U S A 110, no.
This increased in vivo potency has been confirmed in clinical trials in patients with renal failure (Macdougall et al, 1999).
Potency is operationally defined here as the magnitude of drug effects on uptake inhibition across concentrations, where an increase in potency is characterized by increased magnitude of uptake inhibition (greater app. Km) at lower doses of drug.
DAMGO-mediated stimulation increased both in potency and efficacy with aging.
This increase in potency is one reason that high-end strains have become so expensive.
Given there appears no obvious cure for a shaky defence, an increase in potency will be vital.
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