Using structure-guided design, the potency of enzyme inhibition was increased in multiple isozymes from different bacterial species.
The influx of tourists in Kullu Valley, Himachal Pradesh, India has increased in multiple phases increasing from 13,310 in 1979 80 to 67,132 in 1991 92.
The substitution rates thus increase in multiple proteins in the electron transport chain following the divergence of anthropoid primates from tarsiers.
The probability of micelle production is considerably increased in multiple emulsifier systems; in these systems, the transition from a surfactant-poor regime to a surfactant-rich regime could occur at low emulsifier concentrations.
miR-155 demonstrates an average of 50-fold increase in expression in CLL cells tested compared with control B cells (Figure 2D), is increased in multiple cancers [27], [28], [40], and promotes B cell lymphomagenesis [41].
Because the expression and activity of GRK2 are increased in multiple animal models of heart disease and in human heart failure, it has been suggested that enhanced GRK2 activity can explain the concomitantly decreased receptor responsiveness[24].
Moreover, eEF-2 kinase has been found to be overexpressed and its activity increased in multiple breast cancer cell lines and human breast cancer specimens as compared to adjacent normal tissue [10].
In conclusion, expression of REGγ is significantly increased in multiple human cancer types and likely involved in late-stage cancers.
