Both have uncoupling activity in vitro and may mediate the increased energy expenditure implicated in energy balance.
31 This gene encodes a high-mobility group chromatin-associated protein and increased expression is implicated in bone metastasis.
Of these, increased ERα is implicated in the etiology of breast cancers and is often targeted for treatment.
Regarding strain P24, three of the proteins with increased levels were implicated in the lower part of glycolysis and glucose fermentation (Tdh3p, Tdh1p and Gpm1p).
A dysfunctional hypothalamic-pituitary-adrenal (HPA) stress axis and impaired immune responses such as increased cytokines have also been implicated in the increased vulnerability to ELS [ 17, 18].
PTOX has also been implicated in increasing the flux through the linear ETC. and subsequent increased tolerance of photosystems to high light in cold-hardened Arabidopsis thaliana[ 49].
Increases in inorganic nutrients are typical on coral reefs influenced by human activities and have been implicated in increasing severity of fungal infections of corals [71].
There is increasing evidence that abnormal cytokine expression and increased metalloproteinase activity are implicated in the pathophysiology of acute coronary syndromes.
In addition, Azospirillum spp. have been implicated in increasing plant resistance to pathogens (Romero et al. 2003; Tortora et al. 2011).
Both Hsp27 and Hsp90 chaperone proteins have been implicated in increasing the activity of the ubiquitin-proteasome system, though they are not direct participants in the process.
