Its incidence was increased with higher dosages, as previously noted in other studies [11, 12].
Secondly, this therapy was accompanied by dramatic local toxicity, which increased with higher dosages, whereas response rate improved only marginally.
A 10-year study on cannabis use published in the British Medical Journal in 2011 found cannabis to be "an environmental risk factor," increasing the risk of "incident psychotic experiences", and with continued use, increases the risk of "persistent psychotic experiences". Both the article and study show that risk increases with higher dosages.
Their research showed that at a dose of 3 mg/kg amphetamine, a maximum DA release in striatum was achieved which could not be increased by using higher dosages.
26 One might object that glucocorticoid use is an indicator for severe disease, and that the association between increased mortality and higher dosages of glucocorticoids found in our data and in those of others only relates to a persistently high disease activity.
OOF: In an effort to increase sales and push higher dosages of the painkiller OxyContin, Massachusetts Attorney General Maura Healey alleges members of the Sackler family that owns Purdue Pharma engaged in acts of deception and misconduct, our Post colleagues Katie Zezima and Lenny Bernstein report.
For NSAIDs, the OR increased with use of higher dosages (table 4).
However, two of the reviewed studies lacked folic acid supplementation, which might increase the tolerability of higher dosages of methotrexate.
Higher dosages increased RP and initial respiratory rate, and were negatively correlated with serum enzymatic activity (ALT, ALP, CK, AST, and LDH) and serum lactate, urea and triglycerides concentration.
Since it was also suggested that the risk of anaesthetic mortality may increase with the application of higher dosages, we chose not to increase the ketamine-xylazine dosage in this study [ 23].
